So I've fixed the issue on my end. Was using a phenom 2 965 with a R9 x270x which was qualified, and soon as i entered the game it would quit without warning. Did what most folks did on here, updated drivers, framework, directx, updated everything, moved to different drives ssd/hdd, same thing each time. I bought a 8350fx for 70 bucks and popped it in. All of sudden the game is working and silky smooth. Yup so getting a new proc solved my issue. Cant say it will work for the rest maybe help some AMD folks.
August 2018 - last edited August 2018
I think I found the problem, at least for myself. CPU (my case Phenom II X4 965 BE) not supported:
"There is another potential reason for the game to crash on Startup and that is the CPU you are using is an old one and doesn’t support SSE4.2. The game requires a CPU that supports SSE4.2 otherwise it won’t launch the game. Make sure your CPU supports SSE4.2." -SegmentNext
Info found at Ubisoft of all places:
AMD Processors that do not support SSE4.1 or higher