I had just logged into the game and was in the middle of my first contract and was on the third element with "Find this missing Freelancer"
I had just engaged in combat and my PC locked up solid.
Task Manager had no effect.
I ended up having to hit the power button and Hard reboot my PC.
I have had some problems with Anthem performance in the past but nothing this harsh yet.
Hopefully an anomaly and something new and evil.