Are you using any CC or mods? If yes - move the mods folder to the desktop. Delete localthumbcache.package file in the game folder and fix the game in Origin. Origin/Library - right click on TS4 - option "Repair game" You have to wait until Origin will fix all packs, not only the base game.
If you haven't CC or mods delete this file also - the game will create a new one but without saved error and fix the game.