Thursday - last edited Thursday
If you have the sound program Nahimic 2 from MSI installed, disable or uninstall it.
Before opening Origin, close out your Download Management software like Internet Download Manager, Download Accelerator Plus or similar.
Make sure that you run Origin and the game as an administrator. (Set the desktop icons to run Sim4.exe and Origin.exe as administrator)
You can tray also in Origin Library right-click Sim4 icon, option: Game Properties, check the box that says "Disable Origin In-game"
If that still does not help, please run a Clean Boot as this will help with stopping any other programs from interfering
Edit: A tip from Hero puzzlezaddict
Disable the FastBoot app to see whether it helps. (MSI software)