@puzzlezaddict I was using it by clicking on icons, with keyboard commands weird things happened.
So, I've started playing 4 hours ago and game didn't crash and I'm still playing (and making saves every 5 sec, lol). I'm careful to not use this combination that was crashing my game (left button on mouse and pressing scroll button at the same time) and for now it looks like my problem was solved.
I would be thankful if anyone could check this combination in their game. I made new save without mods and CC and it still was crashing my game, weird thing.
@MarRezKermi Do you mean you pressed down on the scroll wheel on your mouse, or that you were using an up or down arrow to scroll, or something else?