The boxed retail versions of Tropico 5 using Kalypso Launcher have been hit by a hideous activation bug which prevents the Launcher from starting up properly.
If you’re affected, please download and install a hotfix restoring Launcher functionality from this location:
[Removed random .exe download - Admin.]
The Fix will auto-install in the correct installation folder for Tropico 5 and the Launcher will then prompt you for any other available updates.
Sorry for the inconvenience!