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[PostHumanWarrior]

If it happens during playing all of your games, it's your windows loosing focus, now it might be or it might not be a background application causing it, the only solutions i know to this problem is either reinstall your whole system like me (cause i'm lazy) or do a clean boot to try and see which program is causing it, here's how to do that: http://support.microsoft.com/kb/331796/en

[_Earsplit]

If it happens during playing all of your games, it's your windows loosing focus, now it might be or it might not be a background application causing it, the only solutions i know to this problem is either reinstall your whole system like me (cause i'm lazy) or do a clean boot to try and see which program is causing it, here's how to do that: http://support.microsoft.com/kb/331796/en

Like I said, it only happens with ME3. No other games and applications in general have ever done this, including Mass Effect and Mass Effect 2.

[Gorath_the_Elder]

It makes zero difference.  The only true cure is removing the offending process causing it, and only the clean boot will ID that process. 

[_Earsplit]

I'll try that out and see if I can isolate the problem.