Did you restarted your PC after each action?
Did you tried both suggestions from this post.
If that don't helps, please create a DxDiag in text file format, also go to your Reliability monitor (Press the windows key and "R" at the same time and copy or type "perfmon /rel" (without the quotes) in > ENTER and look if it has ME2 entries.
If yes double click at the last one, copy it to the clipboard, (Bottom left corner) save it to a text file and load it up together with the DxDiag. You can do that with the "choose file" button at the bottom right corner of the reply window.
The game needs PhysX to be installed to run, regardless of the GPU vendor.
Go to your ">drive<:\Program Files (x86)\Origin Games\Mass Effect 3\__Installer\physx\redist" folder and run the "PhysX-9.11.1107-SystemSoftware.msi" > reboot > test
If that don't helps, Download PhysX from here > install > reboot > test.