April 2017
Why can't I access my paint program after creating a screen shot while playing Mass Effect 3? While in-game, I use the keys Alt + PrtScn, then the windows button to access Paint. When I try to select Paint, it does not work. However, it works fine while I am playing Mass Effect 2. Any help would be appreciated.
April 2017
What exactly do you mean, is Paint not working or is the screenshot black?
If the first, ALT + TAB out of the game, press the Windows key and "R" at the same time and typ or copy and past "mspaint.exe" (without the quotes) into the new window > ENTER.
If the later set ME3 to borderless Windowed mode with the "MassEffect3Config.exe" under ">drive<:\Program Files (x86)\Origin Games\Mass Effect 3\Binaries" (Graphic) .
There are also a lot of tools out there that allow you to make in game screenshots far easier than with the Prt Scrn > Paint method. FRAPS for example.
April 2017
Do you mean the picture is not being pasted into Paint? Try switching the game into Borderless Windowed Mode, that should solve your issue.
An alternate, though more work, option is to add Origin as a 'game' in Steam. Start Steam and then through its interface choose to start Origin, then through Origin start Mass Effect 3. You'll then be able to use Steam's client to take Mass Effect 3 screenshots by pressing F12.