October 2014
Repairing the PhysX ran and completed but did not fix the problem.
(btw - this problem "failed to initialize the physics system" is happening to ME2 as well)
I've tried uninstalling PhysX. reinstalling, and updating but still not fixed...
I've never had a problem running this game before until I bought it again through Origin
This game (games I bought ME1 to 3) is now a waste of money.
January 2015
Thank you! repairing Physx worked
February 2015
Wish I found this post 3 and a half hours ago. Youre a life saver man
February 2015
hey did you ever figure this problem out just bought the game but cant get it to load cause of this error
February 2015
When i went to repair Nividia - Phys X it came up with an old file path of steam... so i uninstalled it - then right clicked on Mass Effect 3 in Origin file and clicked repair - i was then able to load in
September 2015 - last edited September 2015
Trying repair both game and PhysX. Still doesn't working. Have someone any ideas yet?
EDIT: Finally working.
September 2015 - last edited September 2015
Mine still shows the same error.
Edit: Same with the dude above.
December 2015 - last edited December 2015
I have this problem, repairing the PhysX program did nothing. I have a 960 and the latest drivers
March 2016
Just repairing Physx didn't work for me, had to repair ME3 install from Origin library too. That did the trick!
March 2016
I don't seem to have a repair option. When right clicking, I only have the option "Uninstall/change" which when clicked will bring up the uninstall window. What do I do?