Hello Everyone,
I have my solution that worked for this problem, so I hope it will work for you too.
- Navigate to where ever your copy of Mass Effect is located and find you MassEffect.exe file (eg: .../Origin/Mass Effect/Binaries/MassEffect.exe)
- Right click on the MassEffect.exe and then click on "Properties"
- Click on the "Compatibility" tab
- Click on "Run this program in compatibility mode for:" and then select "Windows 7" from the drop down menu
- On the same page then click on the "Run this program as an administrator" box
- Click "Apply" and then "OK"
- Play Mass Effect
This fix worked for me so I hope it works for you all... Enjoy killing Ash (or Kaiden)... who really cares as long as you bro out with Wrex