Unable to play game installed on separate drive

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I am unable to play any game that is installed on a separate drive other than C:

For example, I downloaded plants vs zombies onto a external drive (D and now whenever I try to load it, it instantly crashes. I also tried this with Crysis Remastered and it said something along the lines of "There was a problem with your games setup, please reinstall" so i reinstalled to the same place and it had the same error.