Whenever I play Spore there's this certain rectangle of an area on the screen that you cannot interact with throughout the game. Your mouse changes to default, and you can't click on anything in this. It's getting annoying because my lifeforms can't look the way I'd like with this area being unusable. Any help??
The game may not be played in HD resolution, it does not support this feature.
Try to run the game in windowed mode.
This setting can be found under the graphics settings