Set Graphics to Med/High
actually all u have to really Change is the Settings requiring a new start of the game (should be 2...i think texture Quality and mesh Quality)
worked for me
I've set "Texture Quality" to High(Low didn't load the map & Medium didn't show enemies) and now it's working. I only tested with GM1.
I had this exact issue - 2nd loading screen would trigger after the first and never make it past 15-20% forcing me to Alt+F4 to exit Anthem, then having to close/relog Origin to get Anthem to launch again
Deleting the Bioware folder in Documents, repairing installation (this stopped my random crashes to desktop from Freeplay)
Deleting the Patch folder in the Anthem game folder, reinstalling the patch (which triggered an Origin reinstall) - this let me into a Cataclysm but I couldn't see or interact with anything
Uninstalling the game, reinstalling the game
Clearing my Origin cache (clearing out ProgramData, except LocalContent, and clearing out AppData)
What actually worked:
Setting Texture Quality to High, then queuing up and finishing a Normal difficulty Cataclysm. The game works perfectly now.