February 2017
I have no sound whatsoever in Mass Effect 2 right now. I have tried reinstalling multiple times, repaired the game multiple times, did all of the file stuff, and it still doesn't work. No matter what I do, I get no sound. If anyone has a solution that I haven't tried yet, it would be great if you shared it with me.
February 2017
I assume you're on a PC?
Did you checked the volume sliders in game?
Do you have multiple Audio devices? If so did you ALT+TAB out of the game to see if the right device is used?
If that don't helps create a DxDiag in text file format and post it with your next reply. You can do that with the "choose file" button at the bottom right corner of the reply window.